Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Allen K C Chan
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Ping Yuan
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
Dennis Lo 盧煜明
Professor 教授
Dennis Lo is the Director of the Li Ka Shing Institute of Health Sciences, the Li Ka Shing Professor of Medicine and Professor of Chemical Pathology of The Chinese University of Hong Kong (CUHK). He is also the Associate Dean (Research) of the Faculty of Medicine of CUHK. Dennis Lo received his Bachelor of Arts degree from the University of Cambridge and the Doctor of Medicine and Doctor of Philosophy degrees from the University of Oxford.
Following his training at Oxford, he was appointed as the University Lecturer in Clinical Biochemistry and Honorary Consultant Chemical Pathologist at the John Radcliffe Hospital, the teaching hospital of the University of Oxford Clinical School. He was also a Fellow at Green College, Oxford.
Dennis Lo returned to Hong Kong in 1997. In the same year, he discovered the presence of fetal DNA in maternal plasma. His group has since remained at the forefront of this field. His group was the first to report the presence of cell-free fetal RNA and fetal epigenetic markers in maternal plasma and pioneered the use of such markers for noninvasive prenatal diagnosis. Dennis Lo and his colleagues were also the first to show that cell-free fetal nucleic acids in maternal plasma could be used for the noninvasive prenatal diagnosis of fetal trisomy 21 and had devised multiple solutions for this hitherto difficult diagnostic problem, including methods based on plasma RNA-SNP allelic ratios, plasma epigenetic markers, digital PCR and massively parallel DNA sequencing. With the use of massively parallel sequencing and the development of novel bioinformatics strategies, Dennis Lo’s group succeeded at deciphering a genome-wide genetic map of the fetus through the analysis of the small amounts of fragmented DNA floating in the blood of pregnant women. This scientific achievement lays the foundation for developing non-invasive prenatal diagnostic tests for multiple genetic diseases in a non-invasive way.
In recognition of his work, Dennis Lo has been the recipient of numerous awards, including the 2005 State Natural Science Award from the State Council of China, the 2006 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) – Abbott Award for Outstanding Contribution to Molecular Diagnostics, the 2006 US National Academy of Clinical Biochemistry Distinguished Scientist Award, a Croucher Senior Medical Research Fellowship, the 2007 Sigi Zeiring Award from the American Association of Clinical Chemistry and Fulbright Distinguished Scholar 2009. He was elected as a Fellow of the Royal Society in 2011 and as a Foreign Associate of the US National Academy of Sciences in 2013.
Press conference on December 9, 2010: CUHK researchers decode fetal genomic map from maternal blood
(Lo et al Sci Transl Med 2010;2:61ra91).
Selected publications:
Liao GJW, Lun FMF, Zheng YW, Chan KCA, Leung TY, Lau TK, Chiu RWK, Lo YMD (2011). Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles. Clin Chem 57:92-101.
Lo YMD, Chan KCA, Sun H, Chen EZ, Jiang P, Lun FMF, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RWK (2010). Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2:61ra91.
Yung TKF, Chan KCA, Mok TSK, Tong J, To KF, Lo YMD (2009). Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small cell lung cancer patients. Clin Cancer Res 15:2076-84.
Lun FMF, Tsui NBY, Chan KCA, Leung TY, Lau TK, Charoenkwan P, Chow KCK, Lo WYW, Wanapirak C, Sanguansermsri T, Cantor CR, Chiu RWK, Lo YMD (2008). Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma. Proc Natl Acad Sci U S A 105:19920-5.
Lo YMD, Lun FMF, Chan KCA, Tsui NBY, Chong KC, Lau TK, Leung TY, Zee BC, Cantor CR, Chiu RWK (2007). Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proc Natl Acad Sci U S A 104:13116-21.
Lo YMD, Tsui NBY, Chiu RWK, Lau TK, Leung TN, Heung MM, Gerovassili A, Jin Y, Nicolaides KH, Cantor CR, Ding C (2007). Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat Med 13:218-223.
Lo YMD and Chiu RWK (2007). Prenatal diagnosis: progress through plasma nucleic acids. Nat Rev Genet 8:71-7.
Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu RWK, Panesar NS, Lit LCW, Chan KW, Lo YMD (2003). mRNA of placental origin is readily detectable in maternal plasma. Proc Natl Acad Sci U S A 100:4748-53.
Lo YMD, Chan LYS, Lo KW, Leung SF, Zhang J, Chan ATC, Lee JC, Hjelm NM, Johnson PJ, Huang DP (1999). Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res 59:1188-91.
Lo YMD, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM (1999). Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction. Cancer Res 59:3899-903.
Lo YMD, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM (1999). Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 64:218-24.
Lo YMD, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, Wainscoat JS, Johnson PJ, Chang AM, Hjelm NM (1998). Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 62:768-75.
Lo YMD, Hjelm NM, Fidler C, Sargent IL, Murphy MF, Chamberlain PF, Poon PM, Redman CW, Wainscoat JS (1998). Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med 339:1734-8.
Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS (1997). Presence of fetal DNA in maternal plasma and serum. Lancet 350:485-7.