Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Allen K C Chan
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Ping Yuan
Professor Nancy Tsui
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
 
 
 
Nancy Tsui 徐寶賢
Assistant Professor 助理教授
nancytsui@cuhk.edu.hk
Biography
Dr Nancy Tsui graduated in Biochemistry and received her PhD in Chemical Pathology from the Chinese University of Hong Kong. She next pursued her postdoctoral training in the Department before being appointed as a Research Assistant Professor from 2008. During her PhD and postdoctoral training, Dr Tsui has been awarded the Best Research Output by Research Postgraduate Students from The Chinese University of Hong Kong, the Young Investigator Award from the Fourth International Conference on Circulating Nucleic Acids in Plasma and Serum, and the Postdoctoral Fellowship from the Chinese University of Hong Kong.
 
Dr Tsui is actively involved in research on the biology and clinical applications of circulating fetal nucleic acids in the mother‘s blood. Her research interests include the development of new non-invasive prenatal diagnostic methods by utilizing circulating fetal DNA and RNA, and the investigation of the biological nature of circulating fetal RNA.
 
Ten selected publications:
1:
 Tsui NBY, Kadir RA, Chan KCA, Chi C, Mellars G, Tuddenham EG, Leung TY, Lau TK, Chiu RWK, Lo YMD: Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA. Blood. 2011. (in press, DOI 10.1182/blood-2010-10-310789).
2:
 Tsui NBY, Akolekar R, Chiu RWK, Chow KCK, Leung TY, Lau TK, Nicolaides KH, Lo YMD: Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. Clin Chem. 2010;56: 73-81.
3:
 Tsui NBY, Wong BCK, Leung TY, Lau TK, Chiu RWK, Lo YMD: Non-invasive prenatal detection of fetal trisomy 18 by RNA-SNP allelic ratio analysis using maternal plasma SERPINB2 mRNA: a feasibility study. Prenat Diagn. 2009;29: 1031-7.
4:
 Lun FMF*, Tsui NBY*, Chan KCA, Leung TY, Lau TK, Charoenkwan P, Chow KCK, Lo WY, Wanapirak C, Sanguansermsri T, Cantor CR, Chiu RWK, Lo YMD: Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma. Proc Natl Acad Sci U S A. 2008;105: 19920-5 (*equal contribution).
5:
 Chiu RWK, Chan KCA, Gao Y, Lau VY, Zheng W, Leung TY, Foo CH, Xie B, Tsui NBY, Lun FMF, Zee BC, Lau TK, Cantor CR, Lo YMD: Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A. 2008;105: 20458-63.
6.
 Lo YMD*, Tsui NBY*, Chiu RWK*, Lau TK, Leung TN, Heung MMS, Gerovassili A, Jin Y, Nicolaides KH, Cantor CR, Ding C*: Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat Med. 2007;13: 218-23 (*equal contribution).
7.
 Tsui NBY, Chiu RWK, Ding C, El-Sheikhah A, Leung TN, Lau TK, Nicolaides KH, Lo YMD: Detection of trisomy 21 by quantitative mass spectrometric analysis of single-nucleotide polymorphisms. Clin Chem. 2005;51: 2358-62.
8.
 Tsui NBY, Chim SSC, Chiu RWK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan KCA, Lo YMD: Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling. J Med Genet. 2004;41: 461-7.
9.
 Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu RWK, Panesar NS, Lit LC, Chan KW, Lo YMD: mRNA of placental origin is readily detectable in maternal plasma. Proc Natl Acad Sci U S A. 2003;100: 4748-53.
10.
 Tsui NBY, Ng EKO, Lo YMD: Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem. 2002;48: 1647-53.