Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Allen K C Chan
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Ping Yuan
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
 
 
 
Hao Sun 孫昊
Assistant Professor 助理教授
haosun@cuhk.edu.hk
Biography
Professor Hao Sun is currently an assistant professor and a bioinformatics specialist in the Department of Chemical Pathology. He received his Ph.D. in the field of Environmental Chemistry from Nanjing University, China in 1998 and a M.S. degree in Computer Science from the University of Akron, USA in 2002. Before he joined The Chinese University of Hong Kong in 2009, he worked as a Co-Director of the Bioinformatics Core Facility in Wistar Institute at Philadelphia, USA during 2008 to 2009 and as a Research Scientist/Adjunct Assistant Professor in the Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health, at the Ohio State University, USA from 2001 to 2008.
 
Research Interests:
Professor Sun’s research interests focus on:
(i)
Understanding the fundamental aspects of transcriptional regulation of both coding and noncoding genes;
(ii)
Developing bioinformatics software for Next Generation Sequencing (NGS) data analysis;
(iii)
Developing of new computational algorithms and tools for identifying novel biomarkers, particularly for non-invasive prenatal diagnosis using high-throughput DNA sequencing.
 
His research is computationally driven and interdisciplinary in nature with a complement of collaborative experimental investigation with bench scientists.
 
Selected Publications:
Fiona M. F. Lun, Yoyo Y. Jin, Hao Sun, Tak Y. Leung, Tze K. Lau, Rossa W. K. Chiu, Y. M. Dennis Lo. Non-invasive prenatal diagnosis of Down syndrome due to Robertsonian translocation by massively parallel sequencing of maternal plasma DNA. Clinical Chemistry, 2011
Eric Z Chen, Rossa W.K. Chiu, Hao Sun, Ranjit Akolekar, K.C. Allen Chan, Tak Y. Leung, Peiyong Jiang, Yama W.L. Zheng, Fiona M.F. Lun, Lisa Y. S. Chan, Yongjie Jin, Attie T.J.I. Go, Elizabeth T. Lau, William W.K. To, Wing C. Leung, Rebecca Y.K. Tang, Sidney K.C. Au-Yeung, Helena Lam, Yu Y. Kung, Xiuqing Zhang, John M.G. van Vugt, Ryoko Minekawa, Mary H.Y. Tang, Jun Wang, Cees B.M. Oudejans, Tze K. Lau, Kypros H. Nicolaides, Y.M. Dennis Lo. Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing. PLoS One, 2011.
Y.M. Dennis Lo, K.C. Allen Chan, Hao Sun, Eric Z. Chen, Peiyong Jiang, Fiona M.F. Lun, Yama W. Zheng, Tak Y. Leung, Tze K. Lau, Charles R. Cantor, Rossa W.K. Chiu. Genome-wide fetal genetic and mutational profiling by maternal plasma DNA sequencing. Science Translational Medicine, Dec, 2010
Rossa W K Chiu, Ranjit Akolekar, Yama W L Zheng, Tak Y Leung, Hao Sun, K C Allen Chan, Fiona M F Lun, Attie T J I Go, Elizabeth T Lau, William W K To, Wing C Leung, Rebecca Y K Tang, Sidney K C Au-Yeung, Helena Lam, Yu Y Kung, Xiuqing Zhang, John M G van Vugt, Ryoko Minekawa, Mary H Y Tang, Jun Wang, Cees B M Oudejans, Tze K Lau, Kypros H Nicolaides, Y M Dennis Lo. Non-invasive prenatal diagnosis of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validation study. British Medical Journal, Jan, 2011
Sun Hao, Wu Jiejun, Wickramasinghe Priyankara, Pal Sharmistha, Gupta, Ravi, Bhattacharyya Anirban, Agosto-Perez Francisco, Showe Louise, Huang Tim, Davuluri Ramana. Genome-wide mapping of RNA Pol-II promoter usage in mouse tissue by ChIP-seq. Nucleic Acids Res. 2010, Sept 14, Advance access, 10.1093/nar/gkq775
Milena S. Nicoloso*, Hao Sun*, Riccardo Spizzo, Hyunsoo Kim, Priyankara Wickramasinghe, Masayoshi Shimizu, Sylwia E. Wojcik, Jana Ferdin, Lianchun Xiao, Siranoush Manoukian, Giorgio Secreto, Fernando Ravagnani, Xuemei Wang, Paolo Radice, Carlo M. Croce, Ramana V. Davuluri and George A. Calin. Single nucleotide polymorphisms inside micro-RNA target sites influence tumor susceptibility. Cancer Research. 2010 April 1; 70(7). 2789-2798. (* Equal first author) Rossa W.K. Chiu, Hao Sun, Ranjit Akolekar, Christopher Clouser, Clarence Lee, Kevin Mckernan, Daixing Zhou, Kypros H Nicolaides, and Y.M. Dennis Lo. Maternal plasma DNA analysis using massively parallel sequencing by ligation for noninvasive prenatal diagnosis of trisomy 21. Clinical Chemistry. 2009.
Wang H, Sun, H, Guttridge DC. microRNAs: novel components in a muscle gene regulatory network. Cell Cycle. 2009 Jun 15; 8(12): 1833-7.
Huating Wang, Ramiro Garzon, Hao Sun, Katherine J. Ladner, Ravi Singh, Jason Dahlman, Alfred Cheng, Brett M. Hall, Stephen J. Qualman, Dawn S. Chandler, Carlo M. Croce, and Denis C. Guttridge. NF-κB –YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008 Nov; 14(5): 369-81.
Shery T. Smitha, Priyankara Wickramasinghea, Andrew Olsonb, Dmitri Loukinovc, Lan Lina, Joy Denga, Yanping Xionga, John Ruxa, Ravi Sachidanandamd, Hao Sun, Victor Lobanenkovc and Jumin Zhou. Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. Developmental Biology. 2009 April; 328(2): 518-528.
Huating Wang, Erin Hertlein, Nadine Bakkar, Jingxin Wang, Hao Sun, Ramana Davuluri, and Denis C. Guttridge. NF-kB Regulation of YY1 Inhibits Skeletal Myogenesis through Transcriptional Silencing of Myofibrillar Genes. Molecular Cellular Biology. 2007 Jun; 27(12):4374-87.
R Garzon, F Pichiorri, T Palumbo, M visetini, R Aqeilan, A Cimmion, H Wang, H Sun, S Volnia, H Alder, GA Calin, and CM Croce. MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukaemia. Oncogene, 2007, 26:4148–4157. Sun H, Palaniswamy S, Jin V,Davuluri RV, MPromDb: An integrated resource for annotation and visualization of mammalian gene promoters and ChIP-chip experimental data, Nucleic Acids Research 2006 Database issue.
Palaniswamy SK, James S, Sun H, Davuluri, R.V., Grotewold E. AGRIS and AtRegNet: A platform to link cis-regulatory elements and transcription factors into regulatory networks. Plant Physiology. 2006 Mar, 140(3):818-29.
Saranyan K. Palaniswamy, Victor X, Jin, Hao Sun, Ramana V. Davuluri: OMGProm: A database of promoters of orthologus mammalian genes. Bioinformatics 21(6), 2005.
Victor X. Jin, Hao Sun, Twyla T. Pohar et al (2005). ERTargetDB: an integral information resource of transcription regulation of ER target genes, Journal of Endocrinology, 2005.
Sun H, Davuluri RV: Java-based application framework for visualization of gene regulatory region annotations. Bioinformatics 2004, 20(5):727-734.
Pohar TT, Sun H, Davuluri RV: HemoPDB: Hematopoiesis Promoter Database, an information resource of transcriptional regulation in blood cell development. Nucleic Acids Research 2004, 32 Database issue:D86-90.